Literature summary for 3.1.4.53 extracted from

Suzuki, H.; Sawanishi, H.; Nomura, M.; Shimada, T.; Miyamoto, K.
Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase 4 isoenzyme (2006), Biol. Pharm. Bull., 29, 131-134.

Search for more literature for 3.1.4.53

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2,4-dichlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione	-	Cavia porcellus
rolipram	-	Cavia porcellus

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	isoform PDE4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Cavia porcellus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0001	-	-	Cavia porcellus	rolipram
0.0001	-	-	Cavia porcellus	1-(2,4-dichlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0002	-	-	Cavia porcellus	1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0006	-	-	Cavia porcellus	1-(4-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0009	-	-	Cavia porcellus	1-(4-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0009	-	-	Cavia porcellus	1-(2-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0011	-	-	Cavia porcellus	1-(2-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0012	-	-	Cavia porcellus	1-(3-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0012	-	-	Cavia porcellus	1-benzyl-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.002	-	-	Cavia porcellus	1-(4-methylbenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0024	-	-	Cavia porcellus	1-(3-chlorobenzyl)-7-(2-oxopropyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione
0.0034	-	-	Cavia porcellus	1-(3-methylbenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

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Release 2023.1 (January 2023)