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Literature summary for 3.1.4.53 extracted from

  • Bolger, G.B.; Baillie, G.S.; Li, X.; Lynch, M.J.; Herzyk, P.; Mohamed, A.; Mitchell, L.H.; McCahill, A.; Hundsrucker, C.; Klussmann, E.; Adams, D.R.; Houslay, M.D.
    Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5 (2006), Biochem. J., 398, 23-36.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isoform PDE4D5
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Subunits

Subunits Comment Organism
More signalling scaffold protein RACK, i.e. receptors for activated C-kinase, and beta-arrestin interact with enzyme in mutually exclusive manner at overlapping sites within the N-terminal region of PDE4D5 and at distinct sites within the catalytic domain. Alterations within the level of RACK1 expression may act to modulate signal transduction mediated by beta2-adrenergic receptor through increase in PDE4D5 recruited to the receptor Homo sapiens