Literature summary for 3.1.4.53 extracted from

Murray, F.; Patel, H.H.; Suda, R.Y.; Zhang, S.; Thistlethwaite, P.A.; Yuan, J.X.; Insel, P.A.
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1 (2007), Am. J. Physiol. Lung Cell Mol. Physiol., 292, L294-L303.

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Application

Application	Comment	Organism
medicine	expression of phosphodiesterases PDE1A, PDE1C, PDE3B, and PDE5A is enhanced in pulmonary arterial smooth muscle cells from both patients with idiopathic pulmonary arterial hypertension or secondary pulmonary hypertension compared with control. Increase in phosphodiesterase isoforms, particularly in PDE1C, contributes to decreased cAMP levels and increased proliferation of pulmonary arterial smooth muscle cells in patients with pulmonary hypertension	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with idiopathic pulmonary arterial hypertension or secondary pulmonary hypertension	-

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Release 2023.1 (January 2023)