Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
centrosome | colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region | Mus musculus | 5813 | - |
Golgi apparatus | colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region | Mus musculus | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | Mus musculus | PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase | 5'-AMP | - |
? | |
additional information | Mus musculus | PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
isoform PDE7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
beta-TC3 cell | - |
Mus musculus | - |
beta-TC3 cell | PDE7A1 co-localizes with PKA II in the Golgi centrosome region | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Mus musculus | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase | Mus musculus | 5'-AMP | - |
? | |
cAMP + H2O | isoform PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase | Mus musculus | 5'-AMP | - |
? | |
additional information | PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | isoform PDE7A1 associates with the dissociated C subunit of cAMP dependent protein kinase, but does not bind tetrameric protein kinase holoenzyme. Binding of protein kinase C subunit inhibits kinase activity in vitro, the N-terminal repeat region f PDE7A1 is sufficient for inhibition | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
cAMP-specific phosphodiesterase | - |
Saccharomyces cerevisiae |
PDE7A1 | - |
Mus musculus |
PDE7A1 | - |
Saccharomyces cerevisiae |