Literature summary for 3.1.4.53 extracted from

Ko, W.C.; Shih, C.M.; Lai, Y.H.; Chen, J.H.; Huang, H.L.
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships (2004), Biochem. Pharmacol., 68, 2087-2094.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Biochanin A	IC50: 0.0085 mM, more selectively inhibits PDE4 than PDE1 or PDE2	Cavia porcellus
diosmetin	IC50: 0.0202 mM, PDE4	Cavia porcellus
genistein	IC50: 0.0095 mM, PDE4	Cavia porcellus
hesperetin	IC50: 0.0282 mM, PDE4	Cavia porcellus
luteolin	IC50: 0.0191 mM, PDE4	Cavia porcellus
luteolin-7-glucoside	IC50: 0.043 mM, PDB4, dual inhibition of PDE2 and PDE4	Cavia porcellus
myricetin	IC50: 0.0389 mM, PDE4	Cavia porcellus
prunetin	IC50: 0.0114 mM, PDE4	Cavia porcellus
quercetin	IC50: 0.0099 mM, PDE4	Cavia porcellus

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-

Synonyms

Synonyms	Comment	Organism
PDE4	-	Cavia porcellus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0085	-	IC50: 0.0085 mM, more selectively inhibits PDE4 than PDE1 or PDE2	Cavia porcellus	Biochanin A
0.0095	-	IC50: 0.0095 mM, PDE4	Cavia porcellus	genistein
0.0099	-	IC50: 0.0099 mM, PDE4	Cavia porcellus	quercetin
0.0114	-	IC50: 0.0114 mM, PDE4	Cavia porcellus	prunetin
0.0191	-	IC50: 0.0191 mM, PDE4	Cavia porcellus	luteolin
0.0202	-	IC50: 0.0202 mM, PDE4	Cavia porcellus	diosmetin
0.0282	-	IC50: 0.0282 mM, PDE4	Cavia porcellus	hesperetin
0.0389	-	IC50: 0.0389 mM, PDE4	Cavia porcellus	myricetin
0.043	-	IC50: 0.043 mM, PDB4, dual inhibitionof PDE2 and PDE4	Cavia porcellus	luteolin-7-glucoside

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Release 2023.1 (January 2023)