Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.53 extracted from

  • O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
    Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells (2002), J. Membr. Biol., 185, 137-144.
    View publication on PubMed
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol IC50: 0.31 mM, PDE4 Homo sapiens
(2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one IC50: 0.00043 mM, PDE4 Homo sapiens
Cilostamide IC50: 0.099 mM, PDE4 Homo sapiens
quinazolinamine IC50: 0.34 mM, PDE4 Homo sapiens
RP-73401 IC50: 0.0000016 mM, PDE4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-84 cell PDE4 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDE4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000016
-
 IC50: 0.0000016 mM, PDE4 Homo sapiens RP-73401
0.00043
-
 IC50: 0.00043 mM, PDE4 Homo sapiens (2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
0.099
-
 IC50: 0.099 mM, PDE4 Homo sapiens Cilostamide
0.31
-
 IC50: 0.31 mM, PDE4 Homo sapiens (2R,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
0.34
-
 IC50: 0.34 mM, PDE4 Homo sapiens quinazolinamine