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Literature summary for 3.1.4.52 extracted from

  • Petersen, E.; Chaudhuri, P.; Gourley, C.; Harms, J.; Splitter, G.
    Brucella melitensis cyclic di-GMP phosphodiesterase BpdA controls expression of flagellar genes (2011), J. Bacteriol., 193, 5683-5691.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
Flagellar promoter analysis in the bpdA, bpdB, and cgsB mutants using a luminescent reporter system. Expression in Vibrio parahaemolyticus strain LM5984 Brucella melitensis

Protein Variants

Protein Variants Comment Organism
additional information deletion of bpdA results in a dramatic decrease in flagellar promoter activities, and a flagellar mutant shows similar phenotypes to the bpdA and bpdB mutant strains in mouse models of infection. Genes bpdA and bpdB mutants exhibit decreased dissemination within immunocompetent mice. Flagellar transcription is strongly downregulated in the bpdA mutant Brucella melitensis

Organism

Organism UniProt Comment Textmining
Brucella melitensis
-
 genes bpdA and bpdB
-

Synonyms

Synonyms Comment Organism
BpdA
-
 Brucella melitensis
BpdB
-
 Brucella melitensis
cyclic di-GMP phosphodiesterase
-
 Brucella melitensis

General Information

General Information Comment Organism
malfunction deletion of bpdA results in a dramatic decrease in flagellar promoter activities, and a flagellar mutant shows similar phenotypes to the bpdA and bpdB mutant strains in mouse models of infection. Genes bpdA and bpdB mutants exhibit decreased dissemination within immunocompetent mice Brucella melitensis
physiological function Brucella melitensis cyclic di-GMP phosphodiesterase BpdA controls expression of flagellar genes, regulation of flagella in Brucella melitensis via cyclic-di-GMP Brucella melitensis