Literature summary for 3.1.4.52 extracted from

Kim, Y.K.; McCarter, L.L.
ScrG, a GGDEF-EAL protein, participates in regulating swarming and sticking in Vibrio parahaemolyticus (2007), J. Bacteriol., 189, 4094-4107.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression is sufficient to induce lateral flagellar gene expression in liquid, decrease biofilm formation, decrease cps gene expression, and suppress the DeltascrABC phenotype	Vibrio parahaemolyticus

Protein Variants

Protein Variants	Comment	Organism
D224A	mutation in HDDDF motif, decrease in activity	Vibrio parahaemolyticus
D225A	mutation in HDDDF motif, strong decrease in activity	Vibrio parahaemolyticus
E350A	mutation in EAL motif, almost complete loss of activity	Vibrio parahaemolyticus
F226A	mutation in HDDDF motif, activity similar to wild-type	Vibrio parahaemolyticus
additional information	removal of the EAL domain reverses enzyme activity, converting it to an inhibitor of swarming and activator of cps gene expression	Vibrio parahaemolyticus

Organism

Organism	UniProt	Comment	Textmining
Vibrio parahaemolyticus	-	isoform ScrG, contains GGDEF and EAL domains	-

Synonyms

Synonyms	Comment	Organism
ScrG	-	Vibrio parahaemolyticus

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Release 2023.1 (January 2023)