Literature summary for 3.1.4.50 extracted from

Ritorto, M.S.; Rhode, H.; Vogel, A.; Borlak, J.
Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC (2016), Biol. Chem., 397, 1147-1162 .

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Application

Application	Comment	Organism
medicine	in a c-Myc transgenic disease model of liver cancer, serum GPI-PLD activity is increased 4fold in transgenic mice, while its tissue activity is reduced by 70%	Mus musculus
medicine	in samples from steatohepatitis and hepatocellular carcinoma patients, serum GPI-PLD activity is increased 4fold, while its tissue activity is reduced by 60%. c-Myc influences GPI-AP signaling transcriptionally and posttranslationally and represses GPI-AP anti-proliferative signaling in tumors	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P80108	-	-
Mus musculus	O70362	-	-

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Release 2023.1 (January 2023)