Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | higher activity at low ionic strength, increasing amounts of NaCl, KCl, Na2SO4 or sodium phosphate decrease activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | Ca2+ does not protect | Rattus norvegicus | |
2,2'-dipyridyl | Ca2+ does not protect | Rattus norvegicus | |
Ca2+ | slight decrease of activity above 1 mM, activation at 0.0001-0.01 mM | Rattus norvegicus | |
additional information | no inhibition by 1,7-phenanthroline or 2,2'-dipyridyl | Rattus norvegicus | |
NaHCO3 | kinetics, pH-dependent: at pH 7.5, not at pH 5.5, reversible | Rattus norvegicus | |
NaOCN | kinetics, pH-dependent, reversible | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
phosphatidylinositol-glycan-anchor of membrane form of acetylcholinesterase | 37°C, pH 7.4 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation | Rattus norvegicus | |
Ca2+ | large increase of activity between 0.0001 and 0.01 mM, slight decrease above 1 mM | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O | Rattus norvegicus | isolated from bovine erythrocyte membranes | soluble acetylcholinesterase + phosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-glycan-anchor of membrane form of acetylcholinesterase + H2O | - |
Rattus norvegicus | ? | - |
? | |
phosphatidylinositol-glycan-anchored membrane form of acetylcholinesterase + H2O | isolated from bovine erythrocyte membranes | Rattus norvegicus | soluble acetylcholinesterase + phosphatidic acid | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
higher activity at low ionic strength, increasing amounts of NaCl, KCl, Na2SO4 or sodium phosphate decrease activity | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | about 60% of maximal activity at pH 5 and about half-maximal activity at pH 7, no activity above pH 8.5 | Rattus norvegicus |