BRENDA - Enzyme Database
show all sequences of 3.1.4.50

A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma

Low, M.G.; Prasad, A.R.S.; Proc. Natl. Acad. Sci. USA 85, 980-984 (1988)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
n-butanol
-
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
more effective than EGTA
Homo sapiens
1,10-phenanthroline
more effective than EGTA
Oryctolagus cuniculus
1,10-phenanthroline
more effective than EGTA
Rattus norvegicus
1,10-phenanthroline
-
Bos taurus
EGTA
Ca2+ partially reverses
Homo sapiens
EGTA
Ca2+ partially reverses
Oryctolagus cuniculus
EGTA
Ca2+ partially reverses
Rattus norvegicus
EGTA
-
Bos taurus
additional information
no inhibition by leupeptin
Homo sapiens
additional information
no inhibition by leupeptin; no inhibition by PMSF
Oryctolagus cuniculus
additional information
no inhibition by leupeptin; no inhibition by PMSF
Rattus norvegicus
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
p-Hydroxymercuriphenylsulfonic acid
-
Oryctolagus cuniculus
p-Hydroxymercuriphenylsulfonic acid
-
Rattus norvegicus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation
Oryctolagus cuniculus
Ca2+
activation
Rattus norvegicus
Ca2+
activation
Bos taurus
Ca2+
activation
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
membrane form of variant-surface-glycoprotein + H2O
Gallus gallus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
Rattus norvegicus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
Bos taurus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
Oryctolagus cuniculus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
Canis lupus familiaris
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
Equus caballus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Equus caballus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
fetus
-
Canis lupus familiaris
-
-
-
Equus caballus
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
plasma
heparinized
Homo sapiens
-
plasma
heparinized
Oryctolagus cuniculus
-
plasma
heparinized
Rattus norvegicus
-
plasma
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-nucleotidase + H2O
isolated from rat liver
646473
Rattus norvegicus
?
-
-
-
?
5'-nucleotidase + H2O
isolated from rat liver
646473
Oryctolagus cuniculus
?
-
-
-
?
alkaline phosphatase + H2O
isolated from human placenta
646473
Rattus norvegicus
?
-
-
-
?
alkaline phosphatase + H2O
isolated from human placenta
646473
Oryctolagus cuniculus
?
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Rattus norvegicus
?
-
-
-
-
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Oryctolagus cuniculus
?
-
-
-
-
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
n-butanol
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
more effective than EGTA
Homo sapiens
1,10-phenanthroline
more effective than EGTA
Oryctolagus cuniculus
1,10-phenanthroline
more effective than EGTA
Rattus norvegicus
1,10-phenanthroline
-
Bos taurus
EGTA
Ca2+ partially reverses
Homo sapiens
EGTA
Ca2+ partially reverses
Oryctolagus cuniculus
EGTA
Ca2+ partially reverses
Rattus norvegicus
EGTA
-
Bos taurus
additional information
no inhibition by leupeptin
Homo sapiens
additional information
no inhibition by leupeptin; no inhibition by PMSF
Oryctolagus cuniculus
additional information
no inhibition by leupeptin; no inhibition by PMSF
Rattus norvegicus
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
p-Hydroxymercuriphenylsulfonic acid
-
Oryctolagus cuniculus
p-Hydroxymercuriphenylsulfonic acid
-
Rattus norvegicus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation
Oryctolagus cuniculus
Ca2+
activation
Rattus norvegicus
Ca2+
activation
Bos taurus
Ca2+
activation
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
membrane form of variant-surface-glycoprotein + H2O
Gallus gallus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
Rattus norvegicus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
Bos taurus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
Oryctolagus cuniculus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
Canis lupus familiaris
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
Equus caballus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Equus caballus
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
plasma
heparinized
Homo sapiens
-
plasma
heparinized
Oryctolagus cuniculus
-
plasma
heparinized
Rattus norvegicus
-
plasma
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-nucleotidase + H2O
isolated from rat liver
646473
Rattus norvegicus
?
-
-
-
?
5'-nucleotidase + H2O
isolated from rat liver
646473
Oryctolagus cuniculus
?
-
-
-
?
alkaline phosphatase + H2O
isolated from human placenta
646473
Rattus norvegicus
?
-
-
-
?
alkaline phosphatase + H2O
isolated from human placenta
646473
Oryctolagus cuniculus
?
-
-
-
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
-
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Rattus norvegicus
?
-
-
-
-
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Oryctolagus cuniculus
?
-
-
-
-
Other publictions for EC 3.1.4.50
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749536
Masuda
Impact of glycosylphosphatidy ...
Homo sapiens, Mus musculus, Rattus norvegicus
Am. J. Physiol. Endocrinol. Metab.
316
E239-E250
2019
-
3
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
3
3
3
3
-
-
749993
Ritorto
Regulation of glycosylphospha ...
Homo sapiens, Mus musculus
Biol. Chem.
397
1147-1162
2016
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751919
Jin
Phosphatidylinositol-glycan-p ...
Homo sapiens, Mus musculus
PLoS ONE
10
e0122120
2015
-
2
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
729848
Lindqvist
Plasma glycosylphosphatidylino ...
Homo sapiens
Int. J. Clin. Exp. Med.
5
306-309
2012
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
709821
Raikwar
Glycosylphosphatidylinositol-s ...
Mus musculus, Mus musculus C57BL/6
Metab. Clin. Exp.
59
1413-1420
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
141
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
691854
Jian-Hua
Important roles of glycosylpho ...
Homo sapiens
Clin. Biochem.
42
400-407
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693991
Gray
Plasma glycosylphosphatidylino ...
Homo sapiens
Metab. Clin. Exp.
57
473-478
2008
-
2
-
-
-
1
-
-
1
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-
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-
-
-
1
1
1
1
-
-
680838
Watanabe
Growth factor induction of Cri ...
Homo sapiens
J. Biol. Chem.
282
31643-31655
2007
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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-
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-
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-
-
-
-
-
-
-
-
-
681720
Song
Role of glycosylphosphatidylin ...
Homo sapiens
Leuk. Res.
31
1701-1707
2007
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
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-
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-
-
681749
Song
How Glycosylphosphatidylinosit ...
Homo sapiens
Med. Hypotheses
69
660-665
2007
-
-
-
-
-
-
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-
-
-
-
-
-
1
-
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-
-
-
682945
Deeg
Statin therapy reduces serum l ...
Homo sapiens
Transl. Res.
150
153-157
2007
-
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-
663590
Raikwar
Glycosylphosphatidylinositol-s ...
Mus musculus
Am. J. Physiol.
290
E463-470
2006
-
-
-
-
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-
-
-
-
-
-
1
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2
-
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-
664499
Naghibalhossaini
Evidence for CEA release from ...
Homo sapiens
Cancer Lett.
234
158-167
2006
1
-
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-
-
-
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-
-
1
-
2
-
-
-
-
-
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-
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-
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1
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-
-
-
-
-
-
-
-
-
-
-
668244
Bonilla
Phospholipase cleavage of D- a ...
Bos taurus
Chem. Eur. J.
12
1513-1528
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
6
-
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-
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1
-
-
6
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
669623
Chalasani
Glycosylphosphatidylinositol-s ...
Homo sapiens
J. Clin. Endocrinol. Metab.
91
2279-2285
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
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-
-
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-
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1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
679322
Yoshida
-
Cleavage with phospholipase of ...
Bos taurus
Comp. Biochem. Physiol. B
143B
138-144
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
-
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-
-
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-
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-
-
-
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-
-
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1
-
-
-
-
-
-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681627
Elortza
Modification-specific proteomi ...
Bos taurus
J. Proteome Res.
5
935-943
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
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-
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2
-
-
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-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663876
Yamamoto
Cleavage of carcinoembryonic a ...
Homo sapiens
Biochem. Biophys. Res. Commun.
333
223-229
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
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-
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-
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663968
Raikwar
Mutating His29, His125, His133 ...
Mus musculus
Biochem. J.
391
285-289
2005
-
-
1
-
6
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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1
-
-
6
-
-
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
664464
Gregory
GPI-specific phospholipase D ( ...
Mus musculus
Bone
37
139-147
2005
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
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-
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-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
664631
Jian-Hua
Effect of glycosylphosphatidyl ...
Homo sapiens
Clin. Chim. Acta
359
115-124
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
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1
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663929
Mann
Effect of glycosylphosphatidyl ...
Mus musculus
Biochem. J.
378
641-648
2004
-
-
-
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
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-
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-
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-
-
-
-
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-
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-
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-
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664243
Flores-Borja
Genetic regulation of mouse gl ...
Mus musculus
Biochimie
86
275-282
2004
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666146
Larson
Glycosylphosphatidylinositol-s ...
Homo sapiens
J. Pathol.
203
961-967
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
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-
-
-
-
-
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-
-
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-
-
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-
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-
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-
-
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-
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1
-
-
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1
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666244
Kurtz
Insulin resistance is associat ...
Homo sapiens
Metabolism
53
138-139
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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-
-
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646478
Du
Tolerance of glycosylphosphati ...
Bos taurus
Biochem. J.
361
113-118
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646488
Schofield
Insulin reduces serum glycosyl ...
Homo sapiens, Rattus norvegicus
Mol. Genet. Metab.
75
154-161
2002
-
2
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646489
Slomiany
Screening and modulation of ex ...
Rattus norvegicus
J. Physiol. Pharmacol.
53
21-38
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646475
Bowen
Glucose and insulin regulate g ...
Mus musculus, Rattus norvegicus
Metabolism
50
1489-1492
2001
-
2
-
-
-
-
-
-
1
-
-
2
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646477
Du
Down-regulation of glycosylpho ...
Mus musculus
Infect. Immun.
69
3214-3223
2001
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646486
Rhode
Glycosylphosphatidylinositol-s ...
Homo sapiens
Biol. Chem.
381
471-485
2000
5
-
-
-
-
-
8
-
-
-
1
-
-
2
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
8
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646483
Lee
Regulation of brain glycosylph ...
Bos taurus
Neurochem. Res.
24
1577-1583
1999
2
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646487
Rhode
Glycosylphosphatidylinositol-s ...
Homo sapiens, Rattus norvegicus
Clin. Chim. Acta
281
127-145
1999
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646491
Tsujioka
Intracellular cleavage of glyc ...
Homo sapiens
Biochem. J.
342
449-455
1999
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646493
Wilhelm
Cellular glycosylphosphatidyli ...
Homo sapiens
J. Cell. Physiol.
180
225-235
1999
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646482
Lee
Enzymatic release of Zn2+-glyc ...
Bos taurus
Neurochem. Res.
23
899-905
1998
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
646492
Tsujioka
Posttranslational modification ...
Homo sapiens
Biochem. Biophys. Res. Commun.
251
737-743
1998
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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646494
LeBoeuf
Mouse glycosylphosphatidylinos ...
Mus musculus
Mamm. Genome
9
710-714
1998
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1
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5
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646480
Hari
Uptake and intracellular stabi ...
Bos taurus
Biochim. Biophys. Acta
1355
293-302
1997
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646481
Kueng
Expression of intracellular an ...
Bos taurus
Biochim. Biophys. Acta
1357
329-338
1997
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1
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646490
Stadelmann
The C-terminus of glycosylphos ...
Bos taurus
Biochim. Biophys. Acta
1355
107-113
1997
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1
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646479
Hari
Subcellular distribution of gl ...
Rattus norvegicus
Biochem. J.
320
315-319
1996
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2
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2
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646476
Deeg
Glycosylphosphatidylinositol-p ...
Bos taurus, Homo sapiens
Methods Enzymol.
250
630-640
1995
2
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2
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2
12
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2
2
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2
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1
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2
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1
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12
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1
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2
2
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646485
Maguire
Glycosyl phosphatidyl inositol ...
Homo sapiens
Ann. Clin. Biochem.
32
74-78
1995
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1
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646484
Li
Structural features of GPI-spe ...
Bos taurus
J. Biol. Chem.
269
28963-28971
1994
1
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1
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-
646474
Stieger
Enzymatic properties of phosph ...
Rattus norvegicus
Eur. J. Biochem.
197
67-73
1991
1
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6
1
1
1
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1
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1
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6
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1
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646473
Low
A phospholipase D specific for ...
Bos taurus, Canis lupus familiaris, Equus caballus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
85
980-984
1988
2
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14
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4
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7
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7
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23
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14
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23
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646472
Malik
Conversion of human placental ...
Homo sapiens
Biochem. J.
240
519-527
1986
1
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4
-
1
1
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1
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3
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