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Literature summary for 3.1.4.50 extracted from
- A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma (1988), Proc. Natl. Acad. Sci. USA, 85, 980-984.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| n-butanol | - |
Oryctolagus cuniculus |  |
| n-butanol | activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bos taurus | |
| 1,10-phenanthroline | more effective than EGTA | Homo sapiens | |
| 1,10-phenanthroline | more effective than EGTA | Oryctolagus cuniculus | |
| 1,10-phenanthroline | more effective than EGTA | Rattus norvegicus | |
| EGTA | - |
Bos taurus | |
| EGTA | Ca2+ partially reverses | Homo sapiens | |
| EGTA | Ca2+ partially reverses | Oryctolagus cuniculus | |
| EGTA | Ca2+ partially reverses | Rattus norvegicus | |
| additional information | no inhibition by leupeptin | Homo sapiens | |
| additional information | no inhibition by leupeptin; no inhibition by PMSF | Oryctolagus cuniculus | |
| additional information | no inhibition by leupeptin; no inhibition by PMSF | Rattus norvegicus | |
| p-Hydroxymercuriphenylsulfonic acid | - |
Homo sapiens | |
| p-Hydroxymercuriphenylsulfonic acid | - |
Oryctolagus cuniculus | |
| p-Hydroxymercuriphenylsulfonic acid | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation | Homo sapiens | |
| Ca2+ | activation | Rattus norvegicus | |
| Ca2+ | activation | Bos taurus | |
| Ca2+ | activation | Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| membrane form of variant-surface-glycoprotein + H2O | Gallus gallus | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Homo sapiens | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Rattus norvegicus | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Bos taurus | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Oryctolagus cuniculus | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Canis lupus familiaris | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | Equus caballus | - |
phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
fetus | - |
| Canis lupus familiaris | - |
- |
- |
| Equus caballus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
| plasma | - |
Bos taurus | - |
| plasma | heparinized | Homo sapiens | - |
| plasma | heparinized | Rattus norvegicus | - |
| plasma | heparinized | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-nucleotidase + H2O | isolated from rat liver | Rattus norvegicus | ? | - |
? | |
| 5'-nucleotidase + H2O | isolated from rat liver | Oryctolagus cuniculus | ? | - |
? | |
| alkaline phosphatase + H2O | isolated from human placenta | Rattus norvegicus | ? | - |
? | |
| alkaline phosphatase + H2O | isolated from human placenta | Oryctolagus cuniculus | ? | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Gallus gallus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Homo sapiens | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Rattus norvegicus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Bos taurus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Oryctolagus cuniculus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Canis lupus familiaris | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | - |
Equus caballus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins | Homo sapiens | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins | Rattus norvegicus | phosphatidic acid + variant-surface-glycoprotein inositol | dimyristoylphosphatidic acid | ? | |
| membrane form of variant-surface-glycoprotein + H2O | specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins | Oryctolagus cuniculus | phosphatidic acid + variant-surface-glycoprotein inositol | dimyristoylphosphatidic acid | ? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Gallus gallus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Homo sapiens | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Bos taurus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Canis lupus familiaris | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Equus caballus | phosphatidic acid + variant-surface-glycoprotein inositol | - |
? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Rattus norvegicus | phosphatidic acid + variant-surface-glycoprotein inositol | dimyristoylphosphatidic acid | ? | |
| membrane form of variant-surface-glycoprotein + H2O | phospholipase D-type hydrolysis | Oryctolagus cuniculus | phosphatidic acid + variant-surface-glycoprotein inositol | dimyristoylphosphatidic acid | ? | |
| additional information | little or no activity towards phosphatidylinositol or phosphatidylcholine | Rattus norvegicus | ? | - |
? | |
| additional information | little or no activity towards phosphatidylinositol or phosphatidylcholine | Oryctolagus cuniculus | ? | - |
? | |
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