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Literature summary for 3.1.4.50 extracted from

  • Malik, A.S.; Low, M.G.
    Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases (1986), Biochem. J., 240, 519-527.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.50

Activating Compound

Activating Compound Comment Organism Structure
n-butanol activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Chloropromazine partial Homo sapiens
EGTA Ca2+ partially reverses Homo sapiens
additional information no inhibition by leupeptin; no inhibition by trifluoperazine Homo sapiens
p-Hydroxymercuriphenylsulfonic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
membrane form of variant-surface-glycoprotein + H2O Homo sapiens
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
membrane form of variant-surface-glycoprotein + H2O
-
 Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
membrane form of variant-surface-glycoprotein + H2O cleaves phosphodiester linkage to diacylglycerol Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?