Literature summary for 3.1.4.46 extracted from

Cornelissen, A.; Sadovskaya, I.; Vinogradov, E.; Blangy, S.; Spinelli, S.; Casey, E.; Mahony, J.; Noben, J.P.; Dal Bello, F.; Cambillau, C.; van Sinderen, D.
The baseplate of Lactobacillus delbrueckii bacteriophage Ld17 harbors a glycerophosphodiesterase (2016), J. Biol. Chem., 291, 16816-16827 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	expression of the individual central GDPD domain alone (48.8 kDa) or this domain in combination with the putative carbohydrate-binding domain (73.8 kDa). Both truncated derivatives have lost more than 98% activity in comparison to the full-length GDPD protein	Lactobacillus delbrueckii bacteriophage Ld17

Inhibitors

Inhibitors	Comment	Organism	Structure
Cd2+	5 mM, complete loss of activity	Lactobacillus delbrueckii bacteriophage Ld17
Co2+	5 mM, complete loss of activity	Lactobacillus delbrueckii bacteriophage Ld17
Mn2+	5 mM, complete loss of activity	Lactobacillus delbrueckii bacteriophage Ld17
Ni2+	5 mM, complete loss of activity	Lactobacillus delbrueckii bacteriophage Ld17
Zn2+	5 mM, complete loss of activity	Lactobacillus delbrueckii bacteriophage Ld17

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	optimum activity at 10 mM	Lactobacillus delbrueckii bacteriophage Ld17

Organism

Organism	UniProt	Comment	Textmining
Lactobacillus delbrueckii bacteriophage Ld17	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glycerophosphocholine + H2O	-	Lactobacillus delbrueckii bacteriophage Ld17	choline + glycerol-3-phosphate	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	42	-	Lactobacillus delbrueckii bacteriophage Ld17

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Lactobacillus delbrueckii bacteriophage Ld17

General Information

General Information	Comment	Organism
physiological function	GDPD activity is involved in phage adsorption and/or phage genome injection. The GDPD homotrimer is present in the viral baseplate structure involved in phage-host interaction	Lactobacillus delbrueckii bacteriophage Ld17

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Release 2023.1 (January 2023)