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Literature summary for 3.1.4.45 extracted from
- Purification and characterization of human serum N-acetylgluosamine-1-phosphodiester alpha-N-acetylglucosaminidase (1995), Arch. Biochem. Biophys., 319, 413-425.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CdSO4 | inhibits activity by 20% | Homo sapiens |  |
| CuSO4 | - |
Homo sapiens | |
| diphosphate | - |
Homo sapiens | |
| FeCl2 | - |
Homo sapiens | |
| FeCl3 | - |
Homo sapiens | |
| mannose-6-phosphate | - |
Homo sapiens | |
| N-acetylglucosamine | - |
Homo sapiens | |
| N-acetylglucosamine phosphate | - |
Homo sapiens | |
| PO43- | - |
Homo sapiens | |
| UDP-GlcNAc | - |
Homo sapiens | |
| Zn2+ | inhibits by 50% | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.45 | - |
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose | - |
Homo sapiens | |
| 0.94 | - |
UDP-GlcNAc | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary | - |
Cricetulus griseus | - |
| serum | - |
Homo sapiens | - |
| skin fibroblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 15000 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O | - |
Homo sapiens | N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate | - |
? | |
| UDP-N-acetyl-alpha-D-glucosamine + H2O | - |
Homo sapiens | N-acetyl-D-glucosamine + UDP | - |
? | |
| UDP-N-acetyl-D-glucosamine + H2O | - |
Homo sapiens | UDP + N-acetyl-D-glucosamine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
UDP-GlcNAc | Homo sapiens |
| 6.7 | - |
GlcNAc-phosphomannose alpha-methyl | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9.5 | serum | Homo sapiens |
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