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Literature summary for 3.1.4.41 extracted from

  • Gomes, M.T.; Guimaraes, G.; Frezard, F.; Kalapothakis, E.; Minozzo, J.C.; Chaim, O.M.; Veiga, S.S.; Oliveira, S.C.; Chavez-Olortegui, C.
    Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase (2011), Toxicon, 57, 574-579.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene LiD1, expression in Escherichia coli strain BL21(DE3) Loxosceles intermedia

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme activity is blocked by the anti-loxoscelic antivenom Loxosceles gaucho
additional information enzyme activity is blocked by the anti-loxoscelic antivenom Loxosceles intermedia
additional information enzyme activity is blocked by the anti-loxoscelic antivenom Loxosceles laeta
additional information enzyme activity is blocked by the anti-loxoscelic antivenom Loxosceles similis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Loxosceles laeta
-
-
extracellular
-
Loxosceles intermedia
-
-
extracellular
-
Loxosceles gaucho
-
-
extracellular
-
Loxosceles similis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Loxosceles laeta
Mg2+ required Loxosceles intermedia
Mg2+ required Loxosceles gaucho
Mg2+ required Loxosceles similis

Organism

Organism UniProt Comment Textmining
Loxosceles gaucho
-
-
-
Loxosceles intermedia
-
gene LiD1
-
Loxosceles laeta
-
-
-
Loxosceles similis
-
-
-
no activity in Bothrops jararaca
-
venom
-
no activity in Crotalus durissus
-
venom
-
no activity in Lachesis muta
-
venom
-
no activity in Micrurus frontalis
-
venom
-
no activity in Phoneutria nigriventer
-
venom
-
no activity in Tityus serrulatus
-
venom
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Loxosceles laeta
-
venom
-
Loxosceles intermedia
-
venom
-
Loxosceles gaucho
-
venom
-
Loxosceles similis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1 Loxosceles laeta ceramide 1-phosphate + choline
-
?
sphingomyelin + H2O substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1 Loxosceles intermedia ceramide 1-phosphate + choline
-
?
sphingomyelin + H2O substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1 Loxosceles gaucho ceramide 1-phosphate + choline
-
?
sphingomyelin + H2O substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1 Loxosceles similis ceramide 1-phosphate + choline
-
?

Synonyms

Synonyms Comment Organism
SMase-D
-
Loxosceles laeta
SMase-D
-
Loxosceles intermedia
SMase-D
-
Loxosceles gaucho
SMase-D
-
Loxosceles similis
sphingomyelinase-D
-
Loxosceles laeta
sphingomyelinase-D
-
Loxosceles intermedia
sphingomyelinase-D
-
Loxosceles gaucho
sphingomyelinase-D
-
Loxosceles similis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Loxosceles laeta
37
-
assay at Loxosceles intermedia
37
-
assay at Loxosceles gaucho
37
-
assay at Loxosceles similis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Loxosceles laeta
7.4
-
assay at Loxosceles intermedia
7.4
-
assay at Loxosceles gaucho
7.4
-
assay at Loxosceles similis