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Literature summary for 3.1.4.41 extracted from

  • Paixao-Cavalcante, D.; van den Berg, C.W.; de Freitas Fernandes-Pedrosa, M.; Goncalves de Andrade, R.M.; Tambourgi, D.V.
    Role of matrix metalloproteinases in HaCaT keratinocytes apoptosis induced by loxosceles venom sphingomyelinase D (2006), J. Invest. Dermatol., 126, 61-68.
    View publication on PubMed
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Application

Application Comment Organism
medicine SMaseD induces apoptosis in human keratinocytes, which is associated with an increased expression of metalloproteinase-2 and -9. The use of metalloproteinase inhibitors, such as tetracycline, may prevent cell death and potentially may prevent tissue destruction after envenomation Loxosceles intermedia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Loxosceles intermedia SMaseD induces apoptosis in human keratinocytes, which is associated with an increased expression of metalloproteinase-2 and -9 ?
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 ?

Organism

Organism UniProt Comment Textmining
Loxosceles intermedia P0CE83
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-

Source Tissue

Source Tissue Comment Organism Textmining
venom
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 Loxosceles intermedia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMaseD induces apoptosis in human keratinocytes, which is associated with an increased expression of metalloproteinase-2 and -9 Loxosceles intermedia ?
-
 ?

Synonyms

Synonyms Comment Organism
SMaseD
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 Loxosceles intermedia