Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 46% inhibition at 25 mM | Rattus norvegicus | |
5,5'-dithiobis(2-nitrobenzoic acid) | 16.3% inhibition at 25 mM | Rattus norvegicus | |
cAMP | 19% inhibition at 0.86 mM | Rattus norvegicus | |
CDP | 64% inhibition at 0.86 mM | Rattus norvegicus | |
CMP | 37% inhibition at 0.86 mM, 96% inhibition at 3.8 mM | Rattus norvegicus | |
CTP | 84% inhibition at 0.86 mM | Rattus norvegicus | |
Cu2+ | 38% reduction of enzyme activity at 10 mM | Rattus norvegicus | |
cysteine | 80% inhibition at 25 mM | Rattus norvegicus | |
cytidine | 6.9% inhibition at 0.86 mM | Rattus norvegicus | |
diphosphate | 41% inhibition at 0.86 mM, 82% inhibition at 6.5 | Rattus norvegicus | |
dithiothreitol | 84% inhibition by 25 mM reduced dithiothreitol, 0% inhibition by 25 mM oxidized dithiotreitol | Rattus norvegicus | |
EDTA | 50% inhibition at 0.2 mM | Rattus norvegicus | |
GDPglucose | competitive, 83% inhibition | Rattus norvegicus | |
GDPmannose | competitive, 85% inhibition | Rattus norvegicus | |
glutathione | 62% inhibition by 25 mM reduced glutathione, 15% inhibition by 25 mM oxidized glutathione | Rattus norvegicus | |
N-ethylmaleimide | 5.8% inhibition at 25 mM | Rattus norvegicus | |
p-chloromercuribenzoate | 7.2% inhibition at 25 mM | Rattus norvegicus | |
TDPglucose | competitive, 70% inhibition | Rattus norvegicus | |
UDP | 76% inhibition at 0.86 mM | Rattus norvegicus | |
UDP-N-acetylglucosamine | competitive, 58% inhibition | Rattus norvegicus | |
UDPgalactose | 31% inhibition at 0.86 mM | Rattus norvegicus | |
UDPgalacturonic acid | competitive, 79% inhibition | Rattus norvegicus | |
UDPglucose | competitive, 70% inhibition | Rattus norvegicus | |
UDPglucuronic acid | competitive, 76% inhibition | Rattus norvegicus | |
UDPmannose | competitive, 61% inhibition | Rattus norvegicus | |
UMP | 26% inhibition at 0.86 mM | Rattus norvegicus | |
uridine | 7.5% inhibition at 0.86 mM | Rattus norvegicus | |
UTP | 83% inhibition at 0.86 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
CMP-N-acylneuraminate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
nucleus | - |
Rattus norvegicus | 5634 | - |
plasma membrane | activity in subfractions | Rattus norvegicus | 5886 | - |
plasma membrane | of liver cells | Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | restores 20% of initial enzymatic activity when inhibited by EDTA | Rattus norvegicus | |
Mg2+ | restores 8% of initial enzymatic activity when inhibited by EDTA | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acylneuraminate + H2O | Rattus norvegicus | - |
? | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Rattus norvegicus | - |
bone | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
intestinal mucosa | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
muscle | skeletal | Rattus norvegicus | - |
pancreas | - |
Rattus norvegicus | - |
retina | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, plasma membranes, 1 year, microsomes, 3 months, no loss of activity | Rattus norvegicus |
0°C, for several days no loss of activity, by the 25th day 42% of initial activity remains | Rattus norvegicus |
repeated freezing and thawing, no influence of enzyme activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acylneuraminate + H2O | - |
Rattus norvegicus | CMP + N-acylneuraminate | - |
ir | |
CMP-N-acylneuraminate + H2O | - |
Rattus norvegicus | ? | - |
ir |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
in Tris-HCl buffer | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
EDTA | - |
Rattus norvegicus |