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Literature summary for 3.1.4.4 extracted from
- Differential roles of phospholipase D proteins in FcepsilonRI-mediated signaling and mast cell function (2015), J. Immunol., 195, 4492-4502 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD1 | - |
Mus musculus |
| PLD2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoforms PLD1 and PLD2 regulate different steps in mast cell degranulation. PLD1 deficiency impairs FcepsilonRI-mediated mast cell degranulation while PLD2 deficiency enhances it. PLD deficiency affects activation of the phosphoinositide 3-kinase pathway and RhoA. Although PLD1 deficiency impairs F-actin disassembly, PLD2 deficiency enhances microtubule formation | Mus musculus |
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