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Literature summary for 3.1.4.4 extracted from

  • Jaafar, R.; Zeiller, C.; Pirola, L.; Di Grazia, A.; Naro, F.; Vidal, H.; Lefai, E.; Nemoz, G.
    Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes (2011), J. Biol. Chem., 286, 22609-22621.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
Vasopressin a PLD agonist Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
L-6 myoblast cell
-
 Rattus norvegicus
-
myoblast
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PLD
-
 Rattus norvegicus
PLD1
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function phospholipase D is involved in myogenesis, process modelling with PLD requirement for cell differentiation. PLD is required for S6K1 phosphorylation both the long (p85) and short (p70) S6K1 isoforms are phosphorylated in a PLD1-dependent way, vasopressin stimulation also induces phosphorylation of Akt on Ser-473 through PLD1-dependent activation of mTORC2 complex. Under differentiating conditions, mTORC2 and Akt are activated in a PLD-dependent way. Regulation of mTOR by PLD and myogenic differentiation, overview Rattus norvegicus