Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTP-binding proteins | the PLD1 isoform can be activated by GTP-binding proteins, PKC, and tyrosine kinases. Synergistic activation of PLD1 with combinations of ARF and Rho, Rho and PKC, and ARF and PKC. Isozyme PLD2 remains unaffected by these activators | Homo sapiens | |
phosphatidylinositol-4,5-bisphosphate | required for PLD2 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide | inhibits PLD at the catalytic subunit by competing with phosphatidylinositol-4,5-bisphosphate. Ceramide levels are increased coincidentally with reduced PLD activity in senescent cells. Treatment of cells with ceramide results in a dose-dependent decrease in PLD activity and diacylglycerol accumulation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | PLD is predominantly a membrane-bound enzyme | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | HUVECs | Homo sapiens | - |
additional information | senescent cells show reduced levels of PLD activity. Ceramide levels are increased coincidentally with reduced PLD activity in senescent cells | Homo sapiens | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PLD is suppressed in endothelial cell senescence | down |
General Information | Comment | Organism |
---|---|---|
physiological function | PLD may play a role in mitosis through the production of diacylglycerol, phosphatidic acid, and lysophosphatidic acid | Homo sapiens |