Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP-ribosylation factor 1 | i.e. Arf1, a small G protein, stimulates PLD hydrolytic activity | Homo sapiens | |
ADP-ribosylation factor 6 | i.e. Arf6, a small G protein, stimulates PLD hydrolytic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | downregulation of Arf1 and cytohesin-1 by siRNA leads to reduced PLD transphosphatidylation activity, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
PLB-985 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-lyso-phosphatidylcholine + H2O | - |
Homo sapiens | choline + 1-O-alkyl-2-lyso-phosphatidate | - |
? | |
additional information | PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | polymorphonuclear neutrophil stimulation with fMLP stimulates small G proteins such as ADP-ribosylation factors Arf1 and Arf6, leading to phospholipase D activation and functions such as degranulation and the oxidative burst, regulation, overview | Homo sapiens |