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Literature summary for 3.1.4.4 extracted from

  • El Azreq, M.A.; Garceau, V.; Harbour, D.; Pivot-Pajot, C.; Bourgoin, S.G.
    Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion (2010), J. Immunol., 184, 637-649.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP-ribosylation factor 1 i.e. Arf1, a small G protein, stimulates PLD hydrolytic activity Homo sapiens
ADP-ribosylation factor 6 i.e. Arf6, a small G protein, stimulates PLD hydrolytic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information downregulation of Arf1 and cytohesin-1 by siRNA leads to reduced PLD transphosphatidylation activity, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-
PLB-985 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-lyso-phosphatidylcholine + H2O
-
Homo sapiens choline + 1-O-alkyl-2-lyso-phosphatidate
-
?
additional information PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PLD
-
Homo sapiens

General Information

General Information Comment Organism
physiological function polymorphonuclear neutrophil stimulation with fMLP stimulates small G proteins such as ADP-ribosylation factors Arf1 and Arf6, leading to phospholipase D activation and functions such as degranulation and the oxidative burst, regulation, overview Homo sapiens