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Literature summary for 3.1.4.4 extracted from

  • Zeng, X.X.; Zheng, X.; Xiang, Y.; Cho, H.P.; Jessen, J.R.; Zhong, T.P.; Solnica-Krezel, L.; Brown, H.A.
    Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish (2009), Dev. Biol., 328, 363-376.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Cloned(Commentary)

Cloned (Comment) Organism
gene pld1, in vitro transcription and translation Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information generation of mosaic pld1 deficient embryos, that show partial suppression of intersegmental vessel defects in the segments containing transplanted wild-type somitic and notochord cells, or notochord cells alone. 1-Butanol treatment phenocopies the ISV defects of pld1 morphants, overview. The early chordamesoderm marker shh is normally downregulated in pld1 morphants or 1-butanol treated embryos, ths notochord differentiation is not affected when Pld1 function is disrupted. No changes in VEGF and semaphorins 3a1 expressions Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
1-butanol
-
 Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Danio rerio
-
 choline + phosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
 gene pld1
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-
additional information dynamic expression pattern of pld1 during early zebrafish development, overview Danio rerio
-
notochord
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O
-
 Danio rerio choline + phosphatidic acid
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Danio rerio
PLD1
-
 Danio rerio

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Danio rerio

General Information

General Information Comment Organism
malfunction inhibition of Pld1 function, by siRNA-mediated downregulation or 1-butanol, does not strongly impair the dorsal-ventral guidance of primary/secondary motor axons Danio rerio
physiological function activity of Pld1 in the developing notochord is essential for vascular development in vertebrates. Pld1 may regulate the ISV development through a parallel pathway controlling angiogenesis or play a role downstream of these angiogenic pathways, overview Danio rerio