Activating Compound | Comment | Organism | Structure |
---|---|---|---|
prostaglandin E1 | causes a modest elevation of PLD activity in resting platelets. prostaglandin E1-induced PLD activity is increased by 25% in the presence of Ca2+. Maximal activity at 5 micromol prostaglandin E1 | Homo sapiens | |
thrombin | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
forskolin | inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1, but not PLD2, is inhibited | Homo sapiens | |
prostaglandin E1 | inhibits the activating effect of thrombin; inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1 is inhibited but only at high concentration | Homo sapiens | |
protein kinase A | inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1, but not PLD2, is inhibited | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | translocation to the plasma membrane of PLD1, but not PLD2, is inhibited by forskolin and protein kinase A | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14939 | - |
- |
Homo sapiens | Q13393 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | concentrated platelet-rich plasma is used | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + ethanol | - |
Homo sapiens | choline + phosphatidylethanol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase D1 | - |
Homo sapiens |
phospholipase D2 | - |
Homo sapiens |
PLD1 | - |
Homo sapiens |
PLD2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.4 | - |
assay at | Homo sapiens |