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Literature summary for 3.1.4.4 extracted from

  • Vorland, M.; Holmsen, H.
    Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation (2008), Platelets, 19, 211-224.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
thrombin activation in a dose-dependent manner. Thrombin-induced PLD activity is dependent on autocrine stimulation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane PLD1 and PLD2 are observed over the entire platelet mass. PLD1 is observed in small dots while PLD2 is concentrated close to the membrane. After stimulation with thrombin PLD1 and PLD2 rapidly translocate to the proximity of the plasma membrane of platelets Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ potentiates the activating effect of thrombin but Ca2+ alone does not activate PLD Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14939
-
-
Homo sapiens Q13393
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet concentrated platelet-rich plasma is used Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + ethanol
-
 Homo sapiens choline + phosphatidylethanol
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase D1
-
 Homo sapiens
phospholipase D2
-
 Homo sapiens
PLD1
-
 Homo sapiens
PLD2
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens