Literature summary for 3.1.4.4 extracted from

Iyer, S.S.; Agrawal, R.S.; Thompson, C.R.; Thompson, S.; Barton, J.A.; Kusner, D.J.
Phospholipase D1 regulates phagocyte adhesion (2006), J. Immunol., 176, 3686-3696.

Search for more literature for 3.1.4.4

Activating Compound

Activating Compound	Comment	Organism	Structure
Collagen	adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity	Homo sapiens
fibronectin	adhesion of primary neutrophils and monocyte-derived macrohages as well as myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity	Homo sapiens
additional information	adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	depletion of enzyme by siRNA in macrophages results in significant inhibition of phagocyte adhesion and is accompanied by reductions in total cellular F-actin	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	enzyme exhibits partial co-localization with actin filaments at the adherent interface in proximity to paxilin protein	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	adhesion of primary neutrophils and monocyte-derived macrohages to fibronectin is accompanied by marked stimulation of enzyme activity. Similarly, adhesion of myeloid-macrophage cell lines to fibronectin, collagen, or plastic results in significant activation. Stimulation of enzyme is rapid and persists for at least 90 min	Homo sapiens	-

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Release 2023.1 (January 2023)