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Literature summary for 3.1.4.4 extracted from

  • Cho, J.H.; Hong, S.K.; Kim, E.Y.; Park, S.Y.; Park, C.H.; Kim, J.M.; Kwon, O.J.; Kwon, S.J.; Lee, K.S.; Han, J.S.
    Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells (2007), Biochim. Biophys. Acta, 1783, 912-923.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
taxotere increase in enzyme activity. Overexpression of enzyme isozymes results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3 Homo sapiens

Application

Application Comment Organism
medicine overexpression of enzyme isozymes in SNU 4784 cancer cell results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3. Selective inhibition of phospholipase by specific siRNa leads to exacerbation of taxotere-induced apoptosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in SNU 484 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of enzyme isozymes in SNU 4784 cancer cell results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3. Selective inhibition of phospholipase by specific siRNa leads to exacerbation of taxotere-induced apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme isoform PLD1 and PLD2 are closely related with Bcl-2 expression together with phospholipase A2, but not with phosphatidic acid phosphohydrolase, during taxotere-induced apoptosis in SNU 484 cells ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
SNU-484 cell stomach cancer cell Homo sapiens
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stomach
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme isoform PLD1 and PLD2 are closely related with Bcl-2 expression together with phospholipase A2, but not with phosphatidic acid phosphohydrolase, during taxotere-induced apoptosis in SNU 484 cells Homo sapiens ?
-
?