Activating Compound | Comment | Organism | Structure |
---|---|---|---|
taxotere | increase in enzyme activity. Overexpression of enzyme isozymes results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | overexpression of enzyme isozymes in SNU 4784 cancer cell results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3. Selective inhibition of phospholipase by specific siRNa leads to exacerbation of taxotere-induced apoptosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in SNU 484 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of enzyme isozymes in SNU 4784 cancer cell results in inhibition of taxotere-induced apoptotic cell death, accompanied by up-regulated expression of Bcl-2 and inhibited taxotere-induced activation of procaspase 3. Selective inhibition of phospholipase by specific siRNa leads to exacerbation of taxotere-induced apoptosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme isoform PLD1 and PLD2 are closely related with Bcl-2 expression together with phospholipase A2, but not with phosphatidic acid phosphohydrolase, during taxotere-induced apoptosis in SNU 484 cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SNU-484 cell | stomach cancer cell | Homo sapiens | - |
stomach | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme isoform PLD1 and PLD2 are closely related with Bcl-2 expression together with phospholipase A2, but not with phosphatidic acid phosphohydrolase, during taxotere-induced apoptosis in SNU 484 cells | Homo sapiens | ? | - |
? |