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BRENDA support

Literature summary for 3.1.4.4 extracted from

  • Ohguchi, K.; Banno, Y.; Akao, Y.; Nozawa, Y.
    Involvement of phospholipase D1 in collagen type I production of human dermal fibroblasts (2006), Biochem. Biophys. Res. Commun., 348, 1398-1402.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in dermal fibroblast Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of isoform PLD1, but not PLD2, results in increased procollagen I production in dermal fibroblast. Reduction of isoform PLD1 expression by siRNA is accompanied by diminution of procollagen biosynthesis and also ribosomal S6 kinase 1 phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isoform PLD1 plays a crucial role in collagen type I production through mTOR signaling in dermal fibroblast ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PL D1
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PLD1 plays a crucial role in collagen type I production through mTOR signaling in dermal fibroblast Homo sapiens ?
-
?