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Literature summary for 3.1.4.4 extracted from

  • Benitez-Rajal, J.; Lorite, M.J.; Burt, A.D.; Day, C.P.; Thompson, M.G.
    Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides (2006), Am. J. Physiol. Gastrointest. Liver Physiol., 291, G977-G986.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
ATP extracellular application of nucleotides stimulates enzyme activity and shows a sustained activation of extracellular signal-regulated kinase. Effects on enzyme and extracellular signal-regulated kinase are not additive and not coupled to DNA synthesis. Best effects are with ATP and UTP at 0.01 mM and above Rattus norvegicus
UDP extracellular application of nucleotides stimulates enzyme activity and shows a sustained activation of extracellular signal-regulated kinase. Effects on enzyme and extracellular signal-regulated kinase are not additive and not coupled to DNA synthesis. Best effects are with ATP and UTP at 0.01 mM and above Rattus norvegicus
UTP extracellular application of nucleotides stimulates enzyme activity and shows a sustained activation of extracellular signal-regulated kinase. Effects on enzyme and extracellular signal-regulated kinase are not additive and not coupled to DNA synthesis. Best effects are with ATP and UTP at 0.01 mM and above Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver hepatic stellate cell Rattus norvegicus
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