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Literature summary for 3.1.4.4 extracted from
- Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner (2004), J. Biol. Chem., 279, 16339-16348.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Munc-18-1 | 2 nM is required for 50% inhibition, inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner | Homo sapiens | |
| Munc-18-1 | inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Munc-18-1 is a potent negative regulator of basal PLD activity. EGF stimulation abolishes this interaction | ? | - |
? |  |
| additional information | Rattus norvegicus | Munc-18-1 is a potent negative regulator of basal PLD activity. EGF stimulation abolishes this interaction | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His6-tagged PLD1 | Rattus norvegicus |
| recombinant PLD2 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Munc-18-1 is a potent negative regulator of basal PLD activity. EGF stimulation abolishes this interaction | Homo sapiens | ? | - |
? | |
| additional information | Munc-18-1 is a potent negative regulator of basal PLD activity. EGF stimulation abolishes this interaction | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD1 | - |
Rattus norvegicus |
| PLD2 | - |
Homo sapiens |
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