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Literature summary for 3.1.4.4 extracted from

  • Vinggaard, A.M.; Hansen, H.S.
    Characterization and partial purification of phospholipase D from human placenta (1995), Biochim. Biophys. Acta, 1258, 169-176.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
EDTA
-
Homo sapiens
phosphatidylinositol 4,5-bisphosphate
-
Homo sapiens
propanolol only hydrolase activity Homo sapiens
sphingosine only hydrolase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide
-
Homo sapiens
oleic acid
-
Homo sapiens
Triton X-100
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
phosphatidylcholine
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ not required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipid + alcohol Homo sapiens transphosphaditylation phospholipid + alcohol
-
?
phospholipid + H2O Homo sapiens phosphoric ester hydrolysis phosphatidic acid + alcohol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, partially purified, 4 weeks, 8% loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + ethanol
-
Homo sapiens phosphatidylethanol + choline
-
?
phosphatidylcholine + ethanolamine
-
Homo sapiens phosphatidylethanolamine + choline
-
?
phosphatidylcholine + H2O
-
Homo sapiens 1,2-diacylglycerophosphate + choline
-
?
phospholipid + alcohol transphosphaditylation Homo sapiens phospholipid + alcohol
-
?
phospholipid + H2O phosphoric ester hydrolysis Homo sapiens phosphatidic acid + alcohol
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8 Hepes buffer stimulates Homo sapiens