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Literature summary for 3.1.4.39 extracted from

  • Zhao, J.; He, D.; Berdyshev, E.; Zhong, M.; Salgia, R.; Morris, A.J.; Smyth, S.S.; Natarajan, V.; Zhao, Y.
    Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways (2011), Biochem. J., 439, 45-55.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Cloned(Commentary)

Cloned (Comment) Organism
functional overexpression of V5-tagged ATX and secretion into conditioned medium Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular autotaxin is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
autotaxin
-
 Homo sapiens
lysoPLD
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens lipopolysaccharides challenge induces ATX expression and release into the medium up

General Information

General Information Comment Organism
malfunction a recombinant ATX mutant, lacking lysoPLD activity, or heat-inactived ATX also induces lung epithelial cell migration Homo sapiens
additional information extracelluar ATX binds to the LPA receptor and integrin beta4 complex on A-549 cell surface Homo sapiens
physiological function secreted autotaxin, which exhibits lysophospholipase D activity, stimulates lung epithelial cell migration through lysophosphatidic acid generation-dependent and -independent pathways lung cell migration is a crucial step for re-epithelialization that in turn is essential for remodelling and repair after lung injury, overview. Extracellular ATX stimulates cell migration through G?i-coupled LPA receptors, cytoskeleton rearrangement, phosphorylation of PKC delta and cortactin at the leading edge of migrating cells. Cortactin regulates ATX-V5-induced cell migration Homo sapiens