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Literature summary for 3.1.4.39 extracted from
- Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate (2005), J. Biol. Chem., 280, 21155-21161.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | promotes tumor cell motility, experimental metastasis, and angiogenesis | Streptomyces chromofuscus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Bac-to-Bac baculovirus in Sf9 insect cells | Streptomyces chromofuscus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T210A | inactive mutant | Streptomyces chromofuscus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-myristoyl-lysophosphatidic acid | - |
Streptomyces chromofuscus |  |
| 1-oleoyl-lysophosphatidic acid | - |
Streptomyces chromofuscus | |
| 1-palmitoyl-lysophosphatidic acid | - |
Streptomyces chromofuscus | |
| bis(para-nitrophenyl)phosphate | inhibition above a concentration of 1 mM | Streptomyces chromofuscus | |
| lysophosphatidic acid | 0.001 mM, complexed to albumin, competitive and noncompetitive components | Streptomyces chromofuscus | |
| additional information | not affected by dioleoylphosphatidic acid, 1-oleoyl-glycerol, sphingosine, glycerol 3-phosphate | Streptomyces chromofuscus | |
| sphingosine-1-phosphate | 0.001 mM, complexed to albumin | Streptomyces chromofuscus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
lysophosphatidylcholine | - |
Streptomyces chromofuscus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic vesicle | - |
Streptomyces chromofuscus | 31410 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 125000 | - |
SDS-PAGE | Streptomyces chromofuscus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces chromofuscus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl thymidine 5'-phosphate + H2O | - |
Streptomyces chromofuscus | 4-nitrophenol + thymidine 5'-phosphate | - |
? | |
| bis(para-nitrophenyl)phosphate + H2O | - |
Streptomyces chromofuscus | ? | - |
? | |
| CPF4 + H2O | bis-pNPP-derived probe, in which both phenyl moieties are linked to coumarin and fluorescein, respectively | Streptomyces chromofuscus | ? | - |
? | |
| lysophosphatidylcholine + H2O | - |
Streptomyces chromofuscus | lysophosphatidic acid + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATX | - |
Streptomyces chromofuscus |
| autotaxin | - |
Streptomyces chromofuscus |
| NPP2 | - |
Streptomyces chromofuscus |
| PLD | - |
Streptomyces chromofuscus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00011 | - |
lysophosphatidic acid | - |
Streptomyces chromofuscus | |
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