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Literature summary for 3.1.4.38 extracted from

  • Kanfer, J.N; McCartney, D.G.
    Glycerophosphorylcholine phosphocholine phosphodiesterase activity of rat brain myelin (1989), J. Neurosci. Res., 24, 231-240.
    View publication on PubMed
Search for more literature for 3.1.4.38

Inhibitors

Inhibitors Comment Organism Structure
EDTA reduced activity of 90% with 0.25 mM in myelin Rattus norvegicus
hexyl-beta-glucoside
-
 Rattus norvegicus
p-nitrophenylphosphate competitive inhibitor Rattus norvegicus
p-Nitrophenylphosphorylcholine competitive inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 sn-glycero-3-phosphocholine
-
 Rattus norvegicus
0.3
-
 p-nitrophenylphosphorylthymidine
-
 Rattus norvegicus
0.33
-
 p-nitrophenylphosphocholine
-
 Rattus norvegicus
66.6
-
 4-nitrophenyl phosphate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane myelin Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ is required for maximum activity in brain tissues not in myelin Rattus norvegicus
Zn2+ optimal concentration is 0.25mM Zn2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Rattus norvegicus 4-nitrophenol + phosphate
-
 ?
p-nitrophenylphosphocholine + H2O
-
 Rattus norvegicus p-nitrophenol + choline phosphate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
 presence of Zn2+ increases heat stability Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
 Rattus norvegicus