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Literature summary for 3.1.4.37 extracted from

  • Azarashvili, T.; Krestinina, O.; Galvita, A.; Grachev, D.; Baburina, Y.; Stricker, R.; Reiser, G.
    Identification of phosphorylated form of 2, 3-cyclic nucleotide 3-phosphodiesterase (CNPase) as 46kDa phosphoprotein in brain non-synaptic mitochondria overloaded by calcium (2014), J. Bioenerg. Biomembr., 46, 135-145.
    View publication on PubMed
Search for more literature for 3.1.4.37

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Rattus norvegicus 31966
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, phosphorylated mitochondrial enzyme, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2',3'-cyclic AMP + H2O Rattus norvegicus
-
 2'-AMP
-
 ?
nucleoside 2',3'-cyclic phosphate + H2O Rattus norvegicus
-
 nucleoside 2'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation on Ser and Thr residues. Permeability transition pore inducer Atr is able to stimulate the ATP incorporation into 46 kDa enzyme in the presence of threshold Ca2+, whereas CsA suppresses significantly phosphorylation of the enzyme Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-cyclic AMP + H2O
-
 Rattus norvegicus 2'-AMP
-
 ?
nucleoside 2',3'-cyclic phosphate + H2O
-
 Rattus norvegicus nucleoside 2'-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, phosphorylated mitochondrial enzyme, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
2',3'-cyclic nucleotide 3'-phosphodiesterase
-
 Rattus norvegicus
CNPase
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation might be an important stage of permeability transition pore regulation in mitochondria, revealing an additional function of CNPase outside of myelin structure Rattus norvegicus