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Literature summary for 3.1.4.37 extracted from

  • O'Neill, R.C.; Braun, P.E.
    Selective synthesis of 2',3'-cyclic nucleotide 3'-phosphodiesterase isoform 2 and identification of specifically phosphorylated serine residues (2000), J. Neurochem., 74, 540-546.
    View publication on PubMed
Search for more literature for 3.1.4.37

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant CNP2, expression in 293T human kidney fibroblast cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
M21L CNP2 mutant Rattus norvegicus
S22A CNP2 mutant with reduced phosphate incorporation Rattus norvegicus
S23A CNP2 mutant Rattus norvegicus
S9A CNP2 mutant with reduced phosphate incorporation Rattus norvegicus
S9A/S22A CNP2 double mutant without phosphate incorporation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm abundantly in the cytoplasmic compartments of CNS myelin Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus
48000
-
 x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CNP performs an integral role in myelinogenesis, both isoforms likely play complementary roles in the onset of process outgrowth and ultimately myelination of axons ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats, 1-2 days old, 2 isoforms: CNP1 and CNP2 differing by a 20-amino acid extension exclusive to CNP2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein only CNP2 is phosphorylated in vivo, CNP1 not, Ser-9 of CNP2 is phosphorylated by a 4-beta-phorbol 12,13-dibutyrate-sensitive kinase, likely protein kinase C, and Ser-22 appears to be constitutively phosphorylated, phosphorylation of Ser-9 may provide a molecular switching mechanism for modulating the function of CNP2 distinguishing it functionally from CNP1 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
glial cell oligodendrocyte-enriched cultures of neonatal rat brain glial cells, CNP2 Rattus norvegicus
-
myelin abundantly in the cytoplasmic compartments of CNS myelin Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CNP performs an integral role in myelinogenesis, both isoforms likely play complementary roles in the onset of process outgrowth and ultimately myelination of axons Rattus norvegicus ?
-
 ?
nucleoside 2',3'-cyclic phosphate + H2O
-
 Rattus norvegicus nucleoside 2'-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus