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Literature summary for 3.1.4.35 extracted from

  • Kay?k, G.; Tuezuen, N.?.; Durdagi, S.
    Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development (2017), J. Enzyme Inhib. Med. Chem., 32, 311-330 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(1R,3S)-2-acetyl-1-(2H-1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylate ZINC03024617 Homo sapiens
(1S,3R)-2-acetyl-1-(2H-1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylate ZINC03024615 Homo sapiens
(1S,3S,4aS,9aR)-1-(2H-1,3-benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,4a,9,9a-hexahydro-1H-b-carboline-3-carboperoxoic acid ZINC21986065 Homo sapiens
(2R)-4-[(2H-1,3-benzodioxol-5-yl)methyl]-1-(3-methoxybenzoyl)-N-methylpiperazine-2-carboxamide ZINC24891165 Homo sapiens
(2R)-N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfanyl)butanamide ZINC32995888 Homo sapiens
(2S)-N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-(methylsulfanyl)butanamide ZINC32995890 Homo sapiens
(3R)-1-(2H-1,3-benzodioxole-5-carbonyl)-4-(2-methoxyphenyl)-N-[(pyridin-3-yl)methyl]pyrrolidine-3-carboxamide ZINC36055139 Homo sapiens
(3S)-N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-2-(furan-2-carbonyl)-N-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide ZINC23055991 Homo sapiens
(6R,12aR)-2-propyl-6-(3,4,5-trimethoxyphenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC02092043 Homo sapiens
(6R,12aR)-6-(2H-1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC12360812 Homo sapiens
(6R,12aR)-6-(4-ethoxy-3-methoxyphenyl)-2-(2-methylpropyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC15955458 Homo sapiens
(6R,12aS)-2-methyl-6-(3,4,5-trimethoxyphenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC16031243; ZINC16042566 Homo sapiens
(6R,12aS)-2-propyl-6-(3,4,5-trimethoxyphenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC11692256 Homo sapiens
(6R,12aS)-6-(4-ethoxy-3-methoxyphenyl)-2-(3-methylbutyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC02120502 Homo sapiens
(6S,12aR)-2-benzyl-6-(3,4-dimethoxyphenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC16043001 Homo sapiens
(6S,12aS)-2-methyl-6-(3,4,5-trimethoxyphenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC02093785 Homo sapiens
(6S,12aS)-2-[(furan-2-yl)methyl]-6-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC00490454 Homo sapiens
(6S,12aS)-2-[2-(3,4-dimethoxyphenyl)ethyl]-6-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC26772005 Homo sapiens
(6S,12aS)-6-(2H-1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione ZINC08204637 Homo sapiens
1-[(3R)-1-(2H-1,3-benzodioxol-5-yl)-5-oxopyrrolidine-3-carbonyl]-N-(4-methoxyphenyl)-L-prolinamide ZINC40146722 Homo sapiens
methyl 2-[(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate ZINC29158966 Homo sapiens
N-[(1S)-1-[1-(2H-1,3-benzodioxole-5-carbonyl)piperidin-4-yl]-2-oxo-2-(pyrrolidin-1-yl)ethyl]-2-methylbenzamide ZINC36210867 Homo sapiens
N-[(S)-[(3R)-1-(2H-1,3-benzodioxole-5-carbonyl)piperidin-3-yl](pyridin-2-yl)methyl]acetamide ZINC19020327 Homo sapiens
N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-4-(2,5-dioxopyrrolidin-1-yl)-N-methylbenzamide ZINC23183710 Homo sapiens
sildenafil
-
 Homo sapiens
vardenafil
-
 Homo sapiens
[4-[(1S,2S)-2-(2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]piperazin-1-yl](1H-indol-2-yl)methanone ZINC44448076 Homo sapiens
[4-[(1S,2S)-2-(2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]piperazin-1-yl](1H-indol-3-yl)methanone ZINC44448130 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Homo sapiens
-
 5'-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O76074
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Homo sapiens