Activating Compound | Comment | Organism | Structure |
---|---|---|---|
light | light stimulates PDE6 activation, rapid reduction in cGMP, closure of Na+/Ca2+ channels and reduced Ca2+ influx | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
H620Q | generation of Pde6bH620Q mice as mouse model, knockdown of guanylate cyclase and cGMP-gated Na+/Ca2+ channels, phenotype compared to control C57BL/6J mice, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
photoreceptor cell | - |
Mus musculus | - |
retina | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cGMP phosphodiesterase | - |
Mus musculus |
PDE6 | - |
Mus musculus |
PDE6B | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | during rod phototransduction, cGMP and Ca2+ are regulated by PDE6, guanylate cyclase, and cGMP-gated Na+/Ca2+ channels. The level of cGMP is controlled by opposing activities of PDE6 and guanylate cyclase and, at sufficiently high levels, Na+/Ca2+ channels open to allow increased Ca2+ influx into the rod outer segment | Mus musculus |