Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | specific PDE5 inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pulmonary artery smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGMP phosphodiesterase 5 | - |
Rattus norvegicus |
cGMP-specific phosphodiesterase 5 | - |
Rattus norvegicus |
PDE5 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enhanced cGMP-dependent protein kinase activity by PDE5 inhibition negatively regulates ERK1/2 activity. PDE5 inhibition suppresses serotonin signalling and consequent cellular proliferation in primary cultured pulmonary artery smooth muscle cells | Rattus norvegicus |