Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.35 extracted from

  • Taylor, C.J.; McRobert, L.; Baker, D.A.
    Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis (2008), Mol. Microbiol., 69, 110-118.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.35

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gametocyte
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Plasmodium falciparum 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-PDE
-
 Plasmodium falciparum
PDE
-
 Plasmodium falciparum
phosphodiesterase
-
 Plasmodium falciparum

General Information

General Information Comment Organism
malfunction disruption of the cyclic nucleotide phosphodiesterase PDEdelta gene causes significantly reduced cGMP-PDE activity and greatly reduced ability to undergo gametogenesis Plasmodium falciparum
physiological function PDEdelta plays a crucial role in regulating cGMP levels during sexual development Plasmodium falciparum