Cloned (Comment) | Organism |
---|---|
ectopic expression of the enhanced green fluorescent protein fusion protein of human cone PDE6C in rods of transgenic Xenopus laevis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cone Pgamma subunit | PDE6C is potently inhibited by the recombinant cone and rod Pgamma-subunits with slight selectivity for the cone Pgamma | Homo sapiens | |
rod Pgamma subunit | PDE6C is potently inhibited by the recombinant cone and rod Pgamma-subunits with slight selectivity for the cone Pgamma | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.065 | - |
3',5'-cGMP | recombinant human cone PDE6C, pH and temperature not specified in the publication | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
125000 | - |
recombinant enhanced green fluorescent protein fusion protein of human cone PDE6C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
immunoprecipitation with Dynabeads with Protein G | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | PDE6 shows specificity for cGMP relative to cAMP | Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE6AB | isoform | Homo sapiens |
PDE6C | isoform | Homo sapiens |
phosphodiesterase-6 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4400 | - |
3',5'-cGMP | recombinant human cone PDE6C, pH and temperature not specified in the publication | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.078 | - |
cone Pgamma subunit | recombinant human cone PDE6C, pH and temperature not specified in the publication | Homo sapiens | |
0.105 | - |
rod Pgamma subunit | recombinant human cone PDE6AB, pH and temperature not specified in the publication | Homo sapiens | |
0.14 | - |
cone Pgamma subunit | recombinant human cone PDE6AB, pH and temperature not specified in the publication | Homo sapiens | |
0.155 | - |
rod Pgamma subunit | recombinant human cone PDE6C, pH and temperature not specified in the publication | Homo sapiens |