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Literature summary for 3.1.4.35 extracted from
- Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta (2008), J. Biol. Chem., 283, 29572-29585.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | potent inhibitor of phosphodiesterase-5 | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | Mus musculus | - |
5'-GMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Mus musculus | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE-5 | - |
Mus musculus |
| phosphodiesterase-5 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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