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Literature summary for 3.1.4.35 extracted from
- Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress (2008), Expert Opin. Investig. Drugs, 17, 855-864.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PDE5 inhibition is an efficacious option for the treatment of erectile dysfunction | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| avanafil | TA-1790, highly selective inhibitor of PDE5 | Homo sapiens |  |
| SLx-2101 | inhibits excellent potency both ex vivo and in vivo | Homo sapiens | |
| udenafil | DA-8159 or Zydena, potent PDE5 inhibitor | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | Homo sapiens | - |
5'-GMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| penis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE5 | - |
Homo sapiens |
| phosphodiesterase-5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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