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Literature summary for 3.1.4.35 extracted from

  • Korkmaz, S.; Radovits, T.; Barnucz, E.; Neugebauer, P.; Arif, R.; Hirschberg, K.; Loganathan, S.; Seidel, B.; Karck, M.; Szabo, G.
    Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta (2009), Eur. J. Pharmacol., 615, 155-162.
    View publication on PubMed
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Application

Application Comment Organism
medicine pharmacological inhibition of PDE5 by vardenafil significantly enhances the endothelium-dependent vasorelaxation in aortic rings rats exposed to peroxynitrite. Acute PDE5-inhibition is advantageous in the treatment of endothelial dysfunction induced by disturbed nitric oxide-cGMP pathway due to nitro-oxidative stress Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
 Rattus norvegicus
tadalafil
-
 Rattus norvegicus
vardenafil
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Rattus norvegicus 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Rattus norvegicus
phosphodiesterase type-5
-
 Rattus norvegicus
phosphodiesterase-5
-
 Rattus norvegicus