Literature summary for 3.1.4.35 extracted from

Tsertsvadze, A.; Fink, H.A.; Yazdi, F.; MacDonald, R.; Bella, A.J.; Ansari, M.T.; Garritty, C.; Soares-Weiser, K.; Daniel, R.; Sampson, M.; Fox, S.; Moher, D.; Wilt, T.J.
Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis (2009), Ann. Intern. Med., 151, 650-661.

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Application

Application	Comment	Organism
medicine	oral PDE-5 inhibitors improve erectile functioning. PDE-5 inhibitors are more effective than placebo in improving sexual intercourse success. The proportion of men with improved erections is significantly greater among those treated with PDE-5 inhibitors than with placebo	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	-	Homo sapiens
tadalafil	-	Homo sapiens
vardenafil	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
PDE-5	-	Homo sapiens
phospho-diesterase-5	-	Homo sapiens

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Release 2023.1 (January 2023)