Literature summary for 3.1.4.35 extracted from

Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries (2008), Eur. J. Pharmacol., 582, 102-109.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride	specific inhibitor of PDE5	Homo sapiens
dipyridamole	PDE5 is specifically inhibited by dipyridamole	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O76074	PDE5A	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical artery smooth muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	PDE5 hydrolyses selectively 3',5'-cGMP with high affinity	Homo sapiens	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE5	key enzyme involved in the regulation of the smooth muscle relaxation associated to cGMP	Homo sapiens
PDE5A	isoform	Homo sapiens

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Release 2023.1 (January 2023)