Literature summary for 3.1.4.35 extracted from

Guo, L.W.; Muradov, H.; Hajipour, A.R.; Sievert, M.K.; Artemyev, N.O.; Ruoho, A.E.
The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure (2006), J. Biol. Chem., 281, 15412-15422.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	rod outer segment membrane	Bos taurus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	isoform PDE6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retinal rod	outer segment membrane	Bos taurus	-

Subunits

Subunits	Comment	Organism
More	enzyme forms a catalytic Palphabeta heterodimer in complex with two Pgamma inhibitory subunits. The N-terminal V16-F30 region of inhibitory subunit Pgamma interacts with the Palphabeta GAFa domain, and the Pgamma F73-I87 C-terminus interacts with the Palphabeta catalytic domain, indicating a linear and extended interaction between Pgamma and Palphabeta. Pgamma may interact with Palpha and Pbeta simultaneously	Bos taurus

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Release 2023.1 (January 2023)