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Literature summary for 3.1.4.35 extracted from
- Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6 (2006), J. Biol. Chem., 281, 11780-11786.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoform PDE6 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | isoform PDE6 delta subunit interacts with G protein-coupled receptor IP. Isoprenylation of IP is critical for this interaction, and overexpression of PDE6 delta subunit increases the initial internalization but facilitates the return of IP to the cell surface in presence of agonist. Depletion of PDE6 delta subunit abolishes cicaprost-induced internalization of IP | Homo sapiens |
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