Literature summary for 3.1.4.35 extracted from

Lin, C.S.; Lin, G.; Xin, Z.C.; Lue, T.F.
Expression, distribution and regulation of phosphodiesterase 5 (2006), Curr. Pharm. Des., 12, 3439-3457.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cGMP	allosteric activation	Homo sapiens
additional information	protein kinase G-mediated phosphorylation up-regulates activity, PP1 phosphatase-mediated dephosphorylation down-regulates activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	binding to the active site	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms PDE5, three splice variants: PDE5A1, PDE5A2, PDE5A3. Enzyme promoters are sensitive to cGMP or cAMP stimulation	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	protein kinase G-mediated phosphorylation up-regulates activity, PP1 phosphatase-mediated dephosphorylation down-regulates activity	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	isoform PDE5 is present in all tissues examined, with heart and cardiomycete being contentious. Splice variants PDE5A1 and PDE5A2 are ubiquitous	Homo sapiens	-
smooth muscle	splice variant PDE5A3 is specific to smooth muscle	Homo sapiens	-

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Release 2023.1 (January 2023)