Any feedback?
Literature summary for 3.1.4.35 extracted from
- Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat (2007), Am. J. Physiol. Renal Physiol., 292, F655-F659.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | increased intrarenal isoform PDE5 level mediates the blunted natriuretic response to atrial natriuretic peptide during pregnancy and may contribute to the physiological volume expansion. Atrial natriuretic peptide causes a fall in mean arterial pressure. Intrarenal sildenafil increases the natriuretic response and the rise in fractional excretion of sodium in pregnant rats to the virgin value. | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
pregnant rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | increased intrarenal isoform PDE5 level mediates the blunted natriuretic response to atrial natriuretic peptide during pregnancy and may contribute to the physiological volume expansion | Rattus norvegicus | - |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
