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Literature summary for 3.1.4.35 extracted from

  • Dell'Agli, M.; Galli, G.V.; Bosisio, E.
    Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba (2006), Planta Med., 72, 468-470.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
amentoflavone IC50: 0.0117 mM Homo sapiens
bilobetin IC50: 0.00152 mM Homo sapiens
ginkgetin IC50: 0.00059 mM Homo sapiens
additional information Gingko biloba dimeric flavonoids inhibit the cGMP-specific PDE5A1 Homo sapiens
sciadopitysin IC50: 0.00324 mM Homo sapiens
sequoiaflavone IC50: 0.0199 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant PDE5A1
-

Synonyms

Synonyms Comment Organism
cGMP-phosphodiesterase-5
-
Homo sapiens
PDE5A1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00059
-
IC50: 0.00059 mM Homo sapiens ginkgetin
0.00152
-
IC50: 0.00152 mM Homo sapiens bilobetin
0.00324
-
IC50: 0.00324 mM Homo sapiens sciadopitysin
0.0117
-
IC50: 0.0117 mM Homo sapiens amentoflavone
0.0199
-
IC50: 0.0199 mM Homo sapiens sequoiaflavone